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Zoloft generic sertraline (Zoloft; Tridone Inc; Teva Pharmaceuticals, USA) 50 mg. Single-blind, randomised, parallel, placebo-controlled trial. Primary outcome was change in depressive symptoms; secondary outcomes included global assessment and depression scale (HAM-D). In the placebo-controlled parallel randomised trial, patients taking sertraline who received the 50 mg dose had a significantly lower HAM-D score at week 8 (P=0.049) than those taking sertraline who how much does generic zoloft cost received placebo (mean changes, −0.31* and −0.33* on the HAM-D, respectively; 95%CI: −0.49 to −0.02 P<0.001). In the double-blind randomized trial, a significant decrease in mean HAM-D score was zoloft generic version observed compared with control in all patients by week 8 (P<0.001; 95%CI: −0.40 to −0.02 for the placebo- and placebo-placebo). There was no significant difference (P=0.24) in the primary endpoint HAM-D between groups in the double-blind controlled study. The authors conclude that sertraline was associated with statistically significant reduction in depression scores, but the context of double-blind design, benefit is not robust. The authors further note that benefit did not extend to global assessment. More information available from this article. J Clin Psychiatry 2005, 58(7):823-834: http://www.crd.york.ac.uk/crd/adc/articles/article/1167/1437-9290-6-5 Antidepressant vs placebo in major depressive disorder: a 12-month, randomised double-blind study of the efficacy and tolerability sertraline citalopram in treatment-resistant major depressive disorder The authors compared sertraline 250-300 mg and citalopram 20 mg, both given once a day to 60 patients with treatment-resistant major depressive disorder, for 12 months. At baseline, depression was not treated with antidepressants except antidepressive drugs (eg, selective serotonin reuptake inhibitors [SSRIs], fluoxetine). Patients were randomised to receive a double-blind parallel arm (n=59), and a placebo (n=60). At randomization, patients were randomly allocated 1:1:1 to receive an active antidepressant (sertraline or citalopram) a placebo. At 12 months, sertraline and citalopram were not significantly better than placebo (Hedges g=1.01; 95% CI 0.83 to 1.29; P=0.28), and no difference was observed how much is generic zoloft for the HAM-D response (mean change −0.05; 95)

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This medicine is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), social anxiety disorder (social phobia), and a severe form of premenstrual syndrome called premenstrual dysphoric disorder (PMDD).

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